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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SREBF1 All Species: 25.76
Human Site: S834 Identified Species: 56.67
UniProt: P36956 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P36956 NP_001005291.1 1147 121675 S834 A D G D K E F S D A L G Y L Q
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001095392 1006 107600 V731 T T T G I D P V A K W W A S L
Dog Lupus familis XP_536664 1152 121533 S835 A D G D R E F S D A L G Y L Q
Cat Felis silvestris
Mouse Mus musculus Q9WTN3 1134 120518 S821 A D G D R E F S D A L G Y L Q
Rat Rattus norvegicus P56720 1134 120502 S821 A D G D R E F S D A L G Y L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510556 1117 119248 S808 A D G H R E F S D A L E Y L Q
Chicken Gallus gallus NP_989457 1115 118326 S810 A Q G E G C F S D A L E Y L Q
Frog Xenopus laevis Q6GQ26 1088 119806 S787 E E E S C E F S R A Q E Y L K
Zebra Danio Brachydanio rerio A3KNA7 1099 120302 T802 R E D A G E F T G V L E F L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730449 1113 124436 G794 L P T S S V S G E A E Q L Q Q
Honey Bee Apis mellifera XP_396866 824 93228 V549 G F L C T D K V T I T H C E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 83 88 N.A. 80.3 80.6 N.A. 67.8 63.1 42.2 37.4 N.A. 32 28.4 N.A. N.A.
Protein Similarity: 100 N.A. 84.3 91 N.A. 86.1 86.5 N.A. 75.6 71.7 59.3 53.6 N.A. 46.9 43.5 N.A. N.A.
P-Site Identity: 100 N.A. 0 93.3 N.A. 93.3 93.3 N.A. 80 66.6 40 33.3 N.A. 13.3 0 N.A. N.A.
P-Site Similarity: 100 N.A. 6.6 100 N.A. 100 100 N.A. 86.6 73.3 53.3 53.3 N.A. 20 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 55 0 0 10 0 0 0 0 10 73 0 0 10 0 0 % A
% Cys: 0 0 0 10 10 10 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 46 10 37 0 19 0 0 55 0 0 0 0 0 10 % D
% Glu: 10 19 10 10 0 64 0 0 10 0 10 37 0 10 0 % E
% Phe: 0 10 0 0 0 0 73 0 0 0 0 0 10 0 0 % F
% Gly: 10 0 55 10 19 0 0 10 10 0 0 37 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 0 10 0 0 10 0 0 0 0 10 % K
% Leu: 10 0 10 0 0 0 0 0 0 0 64 0 10 73 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 10 10 0 10 73 % Q
% Arg: 10 0 0 0 37 0 0 0 10 0 0 0 0 0 0 % R
% Ser: 0 0 0 19 10 0 10 64 0 0 0 0 0 10 0 % S
% Thr: 10 10 19 0 10 0 0 10 10 0 10 0 0 0 0 % T
% Val: 0 0 0 0 0 10 0 19 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 10 10 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 64 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _